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KMID : 0043320080310070823
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Archives of Pharmacal Research
2008 Volume.31 No. 7 p.823 ~ p.829
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Chemical Constituents of Acanthus ilicifolius L. and Effect on Osteoblastic MC3T3E1 Cells
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Kiem Phan-Van
Quang Tran Hong
Huong Tran Thu
Nhung Le Thi Hong
Cuong Nguyen Xuan
Minh Chau Van
Choi Eun-Mi
Kim Young-Ho
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Abstract
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A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O--glucopyranoside (5), (-)-lyoniresinol (6), and -amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 () increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.
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KEYWORD
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Acanthus ilicifolius, Acanthaceae, Acancifoliuside, Osteoblast
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